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Introduction of Research
We mainly investigate molecular mechanisms of thermosensation and their physiological significance by focusing on thermosensitive TRP ion channels from insects to mammals. We are also trying to clarify the nociceptive mechanisms at peripheral nerve endings by focusing on TRPV1 and TRPA1. We are doing behavioral analyses of mice lacking the thermosensitive TRP channels. Furthermore, we are cloning the thermosensitive TRP channels genes from various species, which would help us to understand the mechanisms of thermosensation in the evolution. We also utilize fruit flies as a model to investigate temperature preference and adaptation, particularly focusing on regulatory roles of lipid components.