Cardiocirculatory Dynamism Research Group

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Introduction of Research

Cardiocirculatory system is precisely maintained by the multilevel interactions among muscular organs including heart, blood vessels, and skeletal muscles. We aim to elucidate the common mechanism underlying regulation of muscular potentiality via protein-protein interactions, and establish an innovative strategy to promote healthy life expectancy in mammals.
For example, We simulataneously observe morphological changes of mitochondria (remodeling) and fluctuation of their membrane potential (i.e., mitoflash) under various conditions, to read the causal relationship between mitochondrial quality control and muscular stress resilience.

Mitochondrial hyperfission (upper) and membrane depolarization (lower) in rat cardiomyocytes under hypoxic conditions.