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Introduction of Research
A living cell acts as an input-output (I/O) unit, which senses environment and internal states, processes information, and responds appropriately to adapt the changes. Our laboratory is interested in such a system for the information processing controlled by intracellular signaling devises and networks. Especially, we focus on several signal transduction pathways related to cell proliferation, diﬀerentiation, and cell death in mammalian cells, and aim to quantitatively decipher the mechanisms of signaling networks governing cellular decision-making. To this end, we are attempting to visualize, manipulate, and simulate intracellular signaling with ﬂuorescence imaging techniques and computational approaches.