Specially Appointed Associate Professor: Yusuke MIYANARI, Ph.D.
E-mail: miyanari[at]

LINK: Miyanari Group Web Site


We have just open a new lab in early 2014. A fundamental question in biology for us is to understand the mechanisms underlying cell-fate decision. Genomic reprogramming after mammalian fertilization reverts terminally differentiated gametes into toti- or pluripotent state to start a new developmental program. The cell lineage allocation is accompanied by drastic changes in the pattern of gene expression, epigenetic configurations, and nuclear organization. We are interested in a “microscopic” view of the nuclear architecture, which is subnuclear distribution of chromatin and studying functional roles of nuclear dynamics in cell lineage-allocation by deciphering the molecular mechanisms underlying remodeling of nuclear organization and their effects on developmental gene expression, using mouse embryos and ES cells as model systems.


1. Miyanari Y,
A New Approach to Dissect Nuclear Organization:
TALE-Mediated Genome Visualization (TGV). Methods
Mol Biol. 2016;1338:89-97.
2. Miyanari Y,
TAL effector-mediated Genome Visualization (TGV)
Methods, 2014, Sep;69(2):198-204.
3. Miyanari Y#, Birling CZ. And Torres-Padilla ME*,
Live visualization of chromatin dynamics using
fluorescent TALEs, Nature Structural & Molecular
Biology. 2013 Nov;20(11):1321-4.
#Corresponding authors. Highlighted by Nature Methods.
4. Li Y#, Miyanari Y#, Shirane K, Nitta H, Kubota T, Ohashi H,
Okamoto A, Sasaki H. Sequence-specific microscopic
visualization of DNA methylation status at satellite
in individual cell nuclei and chromosomes,Nucleic Acids
Res. 2013 Oct;41(19):e186.   # First authorship
5. Miyanari Y, Torres-Padilla ME.
Control of ground-state pluripotency by allelic regulation
of Nanog. Nature. 2012 Feb 12;483(7390):470-3
6. Miyanari Y, Torres-Padilla ME.
Epigenetic regulation of reprogramming factors towards
pluripotency in mouse preimplantation development.
Curr Opin Endocrinol Diabetes Obes. 2010 Dec;
7. Hiura H, Sugawara A, Ogawa H, John RM, Miyauchi N,
Miyanari Y, Horiike T, Li Y, Yaegashi N, Sasaki H, Kono T,
Arima T. A tripartite paternally methylated region within
the Gpr1-Zdbf2 imprinted domain on mouse

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