MEMBERS

Staff

Visiting Associate Professor: ARAKAWA, Kazuharu, Ph.D.
E-mail: gaou[at]sfc.keio.ac.jp
 
Specially Appointed Assistant Professor:TANAKA, Sae, Ph.D.
E-mail: sae-tanaka[at]ims.ac.jp
 

 

Research

Water is an essential solvent for all living systems. Some organisms, however, including the microscopic microscopic eight-legged animals called the tardigrades, can endure almost complete desiccation by entering an ametabolic state called anhydrobiosis (life-without-water), and they can quickly come back to active life upon rehydration. In this state of suspended animation, tardigrades are known for their extremotolerance, including extreme heat and cold (-273˚C to 100˚C), extreme pressure (vacuum to 7.5GPa), and ionizing radiation (>5000 Gy). One species even survived direct exposure to space vacuum and UV-C for ten days. We conduct multi-comics analyses coupled with advanced molecular biology experiments to uncover the molecular mechanisms underlying anhydrobiosis, and we aim to understand the systematic mechanisms enabling extremotolerance in these species.
 

Reference

-Yoshida Y, Koutsovoulos G, Laetsch DR, Stevens L, Kumar S, Horikawa DD, Ishino K, Komine S, Kunieda T, Tomita M, Blaxter M, Arakawa K*, “Comparative genomics of the tardigrades Hypsibius dujardini and Ramazzottius varieornatus”, PLoS Biol, 2017, 15(7):e2002266.
 
-Arakawa K*, “No evidence for extensive horizontal gene transfer from the draft genome of a tardigrade”, PNAS, 2016, 113(22):E3057.

Back to top of page