Professor: Shigetoshi AONO, Ph.D.
E-mail: aono[at]
Assistant Professor: Norifumi MURAKI, Ph.D.
E-mail: nmuraki[at]



Transition metal ions and metalloproteins play crucial roles in meeting the energy demands of the cell by playing roles in intermediary metabolism and in signal transduction processes. The elucidation of the structure and function of these metalloproteins is central to understanding the regulatory mechanisms associated with biological functioning. We are currently elucidating the structure-function relationships of metalloproteins using experimental methods in the areas of biochemistry, molecular biology, structural biology, inorganic chemistry, and physical chemistry. Our research interest is especially focusing on transition metal ion-containing transcriptional regulators, heme-based gas sensor proteins, and transition metal ions/complexes transport systems.



・Andrea Pavlou, Andreas Loullis, Hideaki Yoshimura, Shigetoshi Aono, and Eftychia Pinakoulaki, Biochemistry, 56, 5309-5317. (2017)

・N. Muraki, C. Kitatsuji, S. Aono, J. Porphyrins & Phthalocyanines., 19, 9-20. (2015)

・N. Muraki, S. Aono, Chem. Lett., 45, 24-26. (2015)

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