MEMBERS

Staff

Professor: Makoto TOMINAGA, Ph.D.
E-mail: tominaga[at]nips.ac.jp
 
Associate Professor: Takaaki SOKABE, Ph.D.
E-mail: sokabe[at]nips.ac.jp
 
Assistant Professor: Shigeru SAITO, Ph.D.
E-mail: sshigeru[at]nips.ac.jp
 
Assistant Professor: Derouiche Sandra, Ph.D.
E-mail: derosand[at]nips.ac.jp
 

 
LINK: Tominaga Group Website
 

Research

We mainly investigate molecular mechanisms of thermosensation and nociception by focusing on TRP ion channels. We are trying to clarify the molecular mechanisms of thermosensation and their physiological significance by focusing on the thermosensitive TRP channels from mammals to insects. We are also trying to clarify the nociceptive mechanisms at peripheral nerve endings by focusing on TRPV1 and TRPA1. We are doing behavioral analyses of mice lacking the thermosensitive TRP channels. Furthermore, we are cloning the thermosensitive TRP channels genes from various species, which would help us to understand the mechanisms of thermosensation in the evolution. We also utilize fruit flies as a model to investigate temperature preference and adaptation, particularly focusing on regulatory roles of lipid components.

 

Reference

・ Derouiche S. et al, TRPV4 heats ups ANO1-dependent exocrine gland fluid secretion. FASEB J. 32 (4): 1841-1854. (2018)

・ Maruyama K. et al, The ATP transporter VNUT mediates induction of Dectin-1-triggered Candida nociception. iScience 6: 306-318. (2018)

・ Sokabe T. et al, A switch in thermal preference in Drosophila larvae depends on multiple rhodopsins. Cell Rep 17 (2): 336-344. (2016)

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