MEMBERS

Staff

Professor: Motohiko NISHIDA, Ph.D.
E-mail: nishida[at]nips.ac.jp
 
Assistant Professor: Takurou TOMITA, Ph.D.
E-mail: tomita[at]nips.ac.jp
 
Specially Appointed Assistant Professor: Tomohiro TANAKA, Ph.D.
(Affiliation: Center for Novel Science Initiative)
E-mail: ttanaka[at]nips.ac.jp
 

 
Link: Nishida Group Website
 
 

Research

Cardiocirculatory system is precisely maintained by the multilevel interactions among muscular organs including heart, blood vessels, and skeletal muscles. We aim to elucidate the mechanisms of stress resilience (i.e., recovery from ischemic and mechanical stress) in cardiocirculatory systems. We aim to elucidate molecular mechanisms underlying regulation of cardiovascular risks by sulfur-based electrophilic/nucleophilic modifications of proteins. We also aim to elucidate the mechanism how exercise promotes vasculogenesis after ischemic stress, and establish an exercise-mimetic therapeutic strategy.

 

Reference

・Nishimura A et al. Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence. Science Signal. 11, eaat5185. (2018)
 
・Shimauchi T et al. TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy. JCI Insight. Aug 3;2(15). pii: 93358. (2017)
 
・Nishimura A et al. The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension. Science Signal. 9(411), ra7. (2016)

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