MEMBERS

Staff

Specially Appointed Associate Professor: Yasuhiro GO, Ph.D.
E-mail: yago[at]nips.ac.jp
 

 
Link: Go Group Website
 

Research

Spatiotemporal transcriptome gene regulations are essential for the construction of brain structure and for proper function. Comprehensive analyses of the dynamics and the architecture of transcriptome in the both wild and diseased animal models also lead to understanding the molecular causality of the human neuropsychiatric disease. Currently we examine the spatiotemporal transcriptome dynamics using the primate brain to identify the spatiotemporal-specific modulating genes from macro-scale to single-cell level. Through this study, we aim to identify the molecular dynamics and trajectories between proper and atypical brain gene expressional networks. Additionally, we perform massive population genetic analysis for the neuropsychiatric related genes in primates to identify an individual that has a spontaneous loss-of-functional (LoF) mutation in the neuropsychiatric genes and aim to make disease primate models for the neuropsychiatric disease.

 

Reference

・Xu C, Li Q, Efimova O, He L, Tatsumoto S, Stepanova V, Oishi T, Udono T, Yamaguchi K, Shigenobu S, Kakita A, Nawa H, Khaitovich P, Go Y. Human-specific features of spatial gene expression and regulation in eight brain regions. Genome Res. 28: 1097-1110. (2018)

・Tatsumoto S, Go Y, Fukuta K, Noguchi H, Hayakawa T, Tomonaga M, Hirai H, Matsuzawa T, Agata K, Fujiyama A. Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing. Sci Rep. 7(1): 13561. (2017)

・Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, Saito N, Iriki A, Ozaki N, Isoda M. Single-neuron and genetic correlates of autistic behavior in macaque. Sci Adv. 2(9): e1600558. (2016)

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