MEMBERS

Staff

Professor: Kazuhiro AOKI, Ph.D.
E-mail: k-aoki[at]nibb.ac.jp
 
Assistant Professor: Yohei KONDO, Ph.D.
E-mail: y-kondo[at]nibb.ac.jp
 

 
LINK: Aoki Group Website
 

Research

A living cell acts as an input-output (I/O) unit, which senses environment and internal states, processes information, and responds appropriately to adapt the changes. Our laboratory is interested in such a system for the information processing controlled by intracellular signaling devises and networks. Especially, we focus on several signal transduction pathways related to cell proliferation, differentiation, and cell death in mammalian cells, and aim to quantitatively decipher the mechanisms of signaling networks governing cellular decision-making. To this end, we are attempting to visualize, manipulate, and simulate intracellular signaling with fluorescence imaging techniques and computational approaches.

 

Reference

・Miura H, Kondo Y, Matsuda M, Aoki K. Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death. Cell Reports, 24:2658-2668. (2018)

・Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh RE, Matsuda M. Propagating Wave of ERK Activation Orients Collective Cell Migration. Developmental Cell, 43, 305–317. (2017)

・Uda Y, Goto Y, Oda S, Kohchi T, Matsuda M, Aoki K. Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling. Proc Natl. Acad. Sci. U.S.A., 114 (45) 11962-11967. (2017)

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